A traditional belief regarding mode of administration of Asparagus racemosus (AR) says that its Ksheerpaka (milk decoction) is more potent as galactogogue than any other form of dosage. The increase in milk production is theorized to be due to the action of released prolactin. In view of this that milk decoction of AR can stimulate more milk production than aqueous decoction in lactating females because of a capacity to stimulate the prolactin release experiments were performed to compare the effect of aqueous and milk decoction of AR on serum prolactin level in lactating female rats. Females were divided into three experimental groups and treatment was given as follows Group I: Normal control, given with vehicle orally. Group II: Received milk decoction of AR in dose of 200 mg/kg p.o. Group III: Received aqueous decoction AR in dose of 200 mg/kg p.o. All groups had received the decoction for six days starting from day 4 to day 9 of lactation. The animals were then euthanized on day 10 and heart blood samples were analyzed using prolactin kit. The serum prolactin level of the treated milk decoction rats showed significant increase (P<0.05) when compared to control group. This study demonstrates that the milk decoction of AR can stimulate more PRL release than aqueous decoction of AR in the female rat.
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